163.105 Total Synthesis of Natural Products
This course is in all assigned curricula part of the STEOP.
This course is in at least 1 assigned curriculum part of the STEOP.

2023S, VO, 2.0h, 3.0EC

Properties

  • Semester hours: 2.0
  • Credits: 3.0
  • Type: VO Lecture
  • Format: Presence

Learning outcomes

After successful completion of the course, students are able to describe the synthesis of different natural products and to explain and compare the required synthetic strategies, key reactions, and methods.

Subject of course

Learning about the total synthesis of molecules, with a focus on stereoselective synthesis. Methods include: coupling methods; stereoselective aldol reactions; stereoselective allylations; macrocyclisations, metathesis reactions; Sharpless epoxidation; glycosylation reactions; solid phase peptide synthesis; selective disulfide bond formation; protein ligations. These methods will be illustrated with specific natural product examples: Everinomycin; Epothilon; Vancomycin; Insulin; HIV1 protease; poly-ubiquitinated alpha-globin; Hexoses; Zaragozic acid; Brevetoxin. Contemporary applications of protein synthesis in biology and medicine will be briefly discussed.

Dates:

- 23.03.2023 (PG)
- 30.03.2023 (PG)
- 20.04.2023 (PG)
- 04.05.2023 (AC)
- 11.05.2023 (AC)
- 25.05.2023 (backup)
- 01.06.2023 (HM)
- 15.06.2023 (HM)

 

Teaching methods

Powerpoint presentations, selected scientific publications

Mode of examination

Oral

Additional information

 

Sharpless-epoxidation + Hexosen (PG)

Dihydroxylation + Zaragozic acid (PG)

Polyethers + Brevetoxin (PG)

Peptide synthesis, disulfide bond formation + insulin (AC)

Protein ligations + HIV1 protease, poly-ubiquitinated alpha-globin (AC)

Glycosylation + Everninomicin (HM)

Makrocyclisation, methathesis + Epothilon (HM)

Atropisomerism + Vancomycin (HM)

 

 

 

Lecturers

Institute

Course dates

DayTimeDateLocationDescription
Thu11:00 - 13:0023.03.2023 - 15.06.2023Seminarraum Lehar 03 Totaksynthese vonNaturstoffen
Total Synthesis of Natural Products - Single appointments
DayDateTimeLocationDescription
Thu23.03.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese von Naturstoffen
Thu30.03.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese vonNaturstoffen
Thu20.04.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese vonNaturstoffen
Thu27.04.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese vonNaturstoffen
Thu04.05.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese vonNaturstoffen
Thu11.05.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese vonNaturstoffen
Thu25.05.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese vonNaturstoffen
Thu01.06.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese vonNaturstoffen
Thu15.06.202311:00 - 13:00Seminarraum Lehar 03 Totaksynthese vonNaturstoffen

Examination modalities

Oral examination

Exams

DayTimeDateRoomMode of examinationApplication timeApplication modeExam
Tue10:00 - 11:0027.02.2024Seminarraum BA 02C oral14.02.2024 00:00 - 26.02.2024 23:59TISSPrüfung Totalsynthese

Course registration

Begin End Deregistration end
02.03.2023 00:00

Curricula

Study CodeObligationSemesterPrecon.Info
066 490 Technical Chemistry Mandatory elective
786 800 Technical Chemistry Not specified
791 800 Technical Chemistry Not specified

Literature

1. Nicolaou/Sorensen : Classics in total synthesis, Wiley VCH, 1996. 2. Nicolaou/Snyder : Classics in total synthesis II, Wiley VCH, 2003. 3. Recent articles from JACS, Science und JOC.

Preceding courses

Continuative courses

Language

English