After successful completion of the course, students are able to describe the synthesis (multistage) and reactivity of organic compounds with CX-(hetero)multiple bonds such as aldehydes and ketones and their derivatives, carboxylic acids and their derivatives (e.g. acid halides, anhydrides, esters, amides, nitriles), simple heterocycles and the corresponding benzo-fused system, as well as the structure of the most important biologically relevant natural substances (fats and oils, carbohydrates, terpenes and steroids, amino acids and proteins, nucleic acids, alkaloids). In addition, they can plan a synthesis pathway for a desired product, from the product classes mentioned above, taking into account protective groups, chemo-, regio-, and stereoselectivity.
Compounds with CX-(hetero)multiple bonds like aldehydes and ketones and their derivatives; carboxylic acids and their derivatives (such as carboxylic acid halides, anhydrides, esters, amides, nitriles); Synthesis and reactivity of poly functional compounds (such as dicarboxylic acids, oxo acids, hydroxy acids, halo acids, conjugated carbonyl compounds, diols, amino alcohols etc.) via synthesis planning - multistep sequences; chemistry of heterocycles; target oriented synthesis, reactions at polyfunctional compounds: foundations of chemo-, regio-, and stereoselectivity; foundations of protecting group chemistry; strategic analysis of target molecules by retro synthesis. Presentation of the most important biomolecules, their structures, synthetic routes and degradation, chemical properties: fats and oils, carbohydrates, terpenes and steroids, amino acids and proteins, nucleic acids, alkaloids.
A written examination on the lecture contents. The exam lasts 120 minutes and consists of 10 tasks. These tasks are composed of:
- 7 questions randomly distributed over the topics carbonyl compounds, carboxyl compounds, condensation reactions and heterocycles
- 3 questions on important chemical compounds in the biological system
A total of 10 points are awarded for the examination; 10.00-8.75 points correspond to a "Very Good", 8.75-7.50 points to a "Good", 7.50-6.25 points to a "Satisfactory", 6.25-5.00 points to a "Sufficient" and less than 5.00 points to a "Non-Sufficient", which means that the examination must be repeated.
