After successful completion of the course, students are able to apply general spects of pharmacodynamics and pharmacokinetics; they adopt an overview for the development of small-molecule drugs from the preclinical phase via clinical phases to market introduction. Students are familiarized with essential mode of action for small-molecule drugs and were introduced to general structure-activity relationships for core drug classes.
basics of drug activity (enzyme-drug interaction, pharmacodynamics, receptor concept, bioisosterism) drug mechanisms (enzyme inhibition and stimulation) development and structure optimization of drugs (SAR, COMFA, etc.) pro-drug/bio-precursor concept pharmacokinetics (ADME - absorption, distrubution, mebatolism, excretion) safety, toxicity, placebo effect regulatory aspects & intellectual property protection major classes of pharma drugs and agrochemicals incl. their corresponding mode of action
Scientific approach employing hypothesis develoment and application within representative examples; reflecting particular problem situations emphasizing on mechanistic aspects.
ATTENTION: due to absence from office the course will start on Nov. 19, 2018!
Context based discussion of representative and novel examples derived from the lecture, in particular considering also the knowledge-based content of the lecture.
